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I am starting my second week of Epogen usage for possible kidney failure and definite anemia. I can not say for sure but it seems to me that he medication does its job. I feel better and I hope the tests I have undergone this evening will show an improvement. My blood pressure is much better now and I think it is all due to Epogen.

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Data was presented demonstrating that MDS patients on ESAs had fewer transfusions than had been historically needed for MDS patients prior to ESAs.

Macrocytic anemia in patients treated with sulphasalazine for rheumatoid arthritis.

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However, data from the 2004 NAPRTCS annual report highlight that 75% to 80% of children on HD therapy will receive short-acting ESA products IV during a standard (3 times per week) HD regimen, whereas a smaller number (15% to 20%) receive it twice a week, and other dosing regimens are uncommon.

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The finding of increased mortality in patients receiving epoetin alfa in the German trial suggests the need to closely monitor patients enrolled in other ongoing trials for adverse outcomes and to evaluate whether the potential benefits for enrolled patients outweigh the risks in these trials.

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CZE), CE-SDS and capillary isoelectric focusing (cIEF).

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Epoetin is a synthetic version of the hormone erythropoietin (EPO), which stimulates production of red blood cells in the bone marrow.

Test systems that have been used include diluted and undiluted human whole blood and isolated PBMCs with or without a solid phase.

The whole process was performed slowly in order to avoid the introduction of air bubbles during the transfer phase.

Erythropoietin has an anti-myeloma effect-a hypothesis based on a clinical observation supported by animal studies.

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Recent research suggests that the reticulocyte hemoglobin content (CHr) test may be more accurate than a standard hemoglobin test for detecting iron deficiency in infants.

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Emerging safety concerns (thrombosis, cardiovascular events, tumor progression, and reduced survival) derived from clinical trials in several cancer and non-cancer populations prompted CMS to review its coverage of erythropoiesis stimulating agents (ESAs).

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However, for patients ages 50 to 75, an ALLO transplant may be an option after reduced intensity treatment.

Similar molecular structure, biological activity and degradation profiles were seen for both mAbs in a liquid formulation filled in the vials and syringes with the one exception: a small but statistically significant difference in subvisible particle levels was noted and attributed to the presence of trace amounts of silicon oil in the syringes.

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Weekly epoetin alfa maintains hemoglobin, improves quality of life, and reduces transfusion in breast cancer patients receiving chemotherapy.

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In 2 open-label studies, Aranesp ä or Epoetin alfa were administered for the correction of anemia in CRF patients who had not been receiving prior treatment with exogenous erythropoietin.

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Johnson's manufacturing process is being investigated as one of the possible causes of the rise in the number of pure red cell aplasia cases, although the company says it hasn't found any problems to date.

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The usual dose is 600 IU per kilogram bodyweight twice a week.

Biologic manufacturing includes multiple steps that may vary between manufacturers, potentially leading to differences between a biosimilar and its reference product that cannot be fully characterized with available analytical methods.

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NESP has several amino acid substitutions, creating two new consensus N-linked carbohydrate attachment sites, which result in five oligosaccharide chains in NESP compared with three on rHuEpo.

It seems likely that the occurrence of cardiovascular events is partly related to the elevation in Hb concentration and Hct.

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Each agent can also be used in fixed and weight-based dosing scenarios.

Successful reintroduction of a different erythropoiesis-stimulating agent after pure red cell aplasia: relapse after successful therapy with prednisone.

How is anemia in chronic kidney disease treated?

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Conclusion: Capacity to raise cardiac output on effort can be used to select candidates for pericardiectomy among patients with subclinical constrictive pericarditis.

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However, this approach cannot be extrapolated to the majority of biopharmaceuticals because current analytical methods are inadequate to fully characterize these complex proteins.

Our analysis demonstrates that, relative to originator ESAs, biosimilar epoetin α is the most cost-efficient ESA to correct anemia and maintain adequate hemoglobin levels in patients with cancer undergoing chemotherapy.

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